Recently the dietary supplements including chromium were used to manage T2DM and improve glycemic control. Furthermore, it is imperative to identify some preventive strategies to decrease the risk of diabetes and its complications. The Diabetes Control and Complication Trial reported that tight blood glucose control noticeably slows the complications of diabetes therefore many diabetic patients struggle to manage their blood glucose levels with existing treatments. This chronic disease results from defects in insulin secretion and/or peripheral insulin resistance, that both deteriorate glycemic control. The prevalence of T2DM is increasing at an alarming rate, so that the number of Iranian adults suffering from diabetes was more than four millions in 2011 and has been raised by 35% over the past years. Type 2 diabetes mellitus (T2DM) remains a serious public health problem, with high rates of morbidity and mortality in low- or middle-income countries. However, the modest beneficial effects of chromium supplementation on insulin resistance as indicated by HOMA-IR and lipid profile were found. In this study, oral supplementation with 400 µg CrPic for eight weeks did not alter FBG concentration as well as anthropometric parameters in individuals with T2DM. Results of analysis of covariance showed that there were significance differences between groups in total cholesterol, low density lipoprotein cholesterol and HOMA-IR at the end of the intervention adjusting for baseline levels (p = 0.035, 0.030 and < 0.001, respectively). ![]() No significant changes were observed for weight, body mass index, and fasting blood glucose (FBG) in both groups while intra-groups changes in homeostatic model assessment for insulin resistance (HOMA-IR) value was significant (p < 0.05). The patients were recommended not to change their normal diet, life style and medication. Anthropometric indices and metabolic factors were measured at the beginning, and at end of the study. One group received 400 µg CrPic per day and the other group took placebo the intervention duration was 8 weeks. The patients with T2DM (n = 52) were randomly allocated into 2 groups. ![]() This study was conducted to evaluate the effects of chromium picolinate (CrPic) supplementation on the glycemic status and lipid profile in patients with T2DM. ![]() Type 2 diabetes mellitus (T2DM) is a serious public health problem accompanies with several complications. The Korean Society of Clinical NutritionĮffects of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers in Patients with Type 2 Diabetes Mellitus: a Randomized Clinical TrialĪria Tavakoli Talab, 1 Hadi Abdollahzad, 2 Seyyed Mustafa Nachvak, 2 Yahya Pasdar, 2 Shahryar Eghtesadi, 3 Azimeh Izadi, 4 Mir Amir Aghdashi, 5 Mohammad Reza Mohammad Hossseini Azar, 5 Sedighe Moradi, 6 Behzad Mehaki, 7ġBe'sat Hospital, Hamadan University of Medical Sciences, Hamadan 6517838678, Iran.ĢDepartment of Nutrition, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851351, Iran.ģIslamic Azad University Tehran Medical Branch and Science & Research Branch, Tehran 1477983855, Iran.ĤStudents' Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.ĥDepartment of Internal Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5714783734, Iran.ĦEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran 1593716615, Iran.ħDepartment of Biostatistics, Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
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